Overview:
Our laboratory uses mass spectrometry-based proteomics to investigate cellular processes related to protein homeostasis. We study the mechanisms of cellular protein folding, degradation and repair from a global perspective. We also investigate how these processes are affected by disease and aging. Current research areas include:
- developing proteomic methodologies for analysis of protein folding, oxidation and degradation
- identifying factors that influence methionine oxidation and repair
- deciphering the role of the ribosome in co-translational folding of nascent proteins
- uncovering mechanisms of selectivity in protein degradation pathways
- understanding the relationship between protein turnover and aging
If you are interested in joining our lab as an undergraduate researcher, graduate student or a postdoctoral fellow, please first read our FAQs and contact Dr. Ghaemmaghami if you have additional questions.
Latest Publication:
