Overview:
Our laboratory uses mass spectrometry-based proteomics to investigate cellular processes related to protein homeostasis. We study the mechanisms of cellular protein folding, degradation and repair from a global perspective. We also investigate how these processes are affected by disease and aging. Current research areas include:
- developing proteomic methodologies for analysis of protein folding, oxidation and degradation
- identifying factors that influence methionine oxidation and repair
- uncovering mechanisms of selectivity in macroautophagy
- determining the cellular basis of toxicity of prion aggregates
- understanding the relationship between protein turnover and aging
Latest Publication:
